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US 4,237,225 AGranted
Process for preparing tunicamycin
AssigneeEli Lilly and Company
InventorRobert L. Hamill
Life of this patent
Estimating the term…
Abstract
Tunicamycin is co-produced with antibiotic A-23187 by the cultivation of Streptomyces chartreusis NRRL 3882. Methods of recovering tunicamycin and for separating and isolating individual factors A, B, C, and D from tunicamycin complex are described.
Claims5
A method for preparing tunicamycin which comprises cultivating Streptomyces chartreusis NRRL 3882 in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic conditions until a substantial amount of tunicamycin is produced;
- separating tunicamycin from co-produced antibiotic A-23187;
- and isolating tunicamycin.
Dependencies are inferred from the claim text.