Benzyl-phenoxy acid esters and hyperlipaemia compositions containing the same
AssigneeOrchimed SA
InventorAndre Mieville
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Abstract
Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholosterolaemiant and cholagogic agents or in the preparation of such agents.
Claims10
A compound of formula II ##STR227## wherein X.sub.1, X.sub.2 and X.sub.3 are the same or different and represent H, Cl, Br, F, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, benzyloxy, acetamido, acetoxy, CHO, COOH or a group of the formula --O--C(CH.sub.3).sub.2 --COY.sup.1 wherein Y.sup.1 is OH or C.sub.1 -C.sub.4 alkoxy;
- R, X.sub.4 and X.sub.5 are the same or different and represent hydrogen or C.sub.1-4 alkyl;
- R' represents H, C.sub.1-4 alkyl, or acetyl;
- and
- Y represents a O--CH.sub.2 --CH.sub.2 --NZ.sub.1 Z.sub.2 group wherein Z.sub.1 and Z.sub.2 each are C.sub.1-4 alkyl or Z.sub.1 and Z.sub.2 together represent alkylene which with the nitrogen atom to which they are bond forms a 5 to 7 membered N-heterocyclus;
- or an acid addition salt thereof.
A compound of the formula:
- ##STR228## wherein X.sub.1 is hydrogen or chlorine, R is CH.sub.3, R' is hydrogen and Y represents a group of the formula ##STR229##
Dependencies are inferred from the claim text.