Process for preparing thienylglyoxylic acids and amides
AssigneeStauffer Chemical Company
InventorJames M. Photis
Life of this patent
Estimating the term…
Abstract
Thienylglyoxylic acids and/or amides thereof are prepared by reacting thiophene carboxylic acid chloride with sodium cyanide and hydrolyzing the resulting product in a strong mineral acid.
Claims9
A process for preparing thienylglyoxyl compounds represented by the structure ##STR9## wherein R represents hydrogen, a halogen, an alkyl group having from 1 to about 8 carbon atoms, a cycloalkyl group having from 1 to about 8 carbon atoms or any combination thereof, and wherein R.sup.1 represents NH.sub.2 or OH which comprises reacting a thiophene carboxylic acid chloride with aqueous sodium cyanide in an inert, water-immiscible solvent in the presence of a phase transfer catalyst to form a thiophene carboxylic acid cyanide and reacting said thiophene acid cyanide with a strong mineral acid at a temperature and for a time sufficient to form said compound.
A process for preparing thienylglyoxylic acid which comprises reacting thiophene carboxylic acid chloride with aqueous sodium cyanide in methylene chloride solvent and in the presence of a phase transfer catalyst to form thiophene carboxylic acid cyanide and then reacting said thiophene carboxylic acid cyanide with concentrated hydrochloric acid at a temperature and for a time sufficient to form thienylglyoxylic acid.
A process for preparing thienylglyoxamide which comprises reacting thiophene carboxylic acid chloride with aqueous sodium cyanide in methylene chloride solvent and in the presence of a phase transfer catalyst to form thiophene carboxylic acid cyanide and reacting said thiophene carboxylic acid cyanide with concentrated hydrochloric acid at a temperature and for a time sufficient to form thienylglyoxamide.
Dependencies are inferred from the claim text.