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US 4,234,596 AGranted
3-(2-Aminoethyl thio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
AssigneeMerck & Co., Inc.
InventorsBurton G. Christensen, David B. R. Johnston, Susan M. Schmitt
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Abstract
Isomeric forms of 3-(2-aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en e-2-carboxylic acid (I) ##STR1## are disclosed; also disclosed is a process for their total synthesis; such isomers individually, and as mixtures, are useful as antibiotics.
Claims12
A compound having the structural formula:
- ##STR67## which has the absolute configuration 5S,6S,8R and the pharmaceutically acceptable salts thereof.
A compound having the structural formula:
- ##STR68## which has the absolute configuration 5R,6R,8R and the pharmaceutically acceptable salts thereof.
A compound having the structural formula:
- ##STR69## which has the absolute configuration 5S,6S,8S and the pharmaceutically acceptable salts thereof.
A compound having the structural formula:
- ##STR70## which has the absolute configuration 5S,6R,8R and the pharmaceutically acceptable salts thereof.
A compound having the structural formula:
- ##STR71## which has the absolute configuration 5S,6R,8S and the pharmaceutically acceptable salts thereof.
A mixture comprising two or more isomers of a compound having the structural formula:
- ##STR72## which isomers, in terms of their absolute configuration relative to the above structure are selected from the group consisting of:
- 5R,6R,8S;
- 5S,6S,8R;
- 5R,6R,8R;
- 5S,6S,8S;
- 5R,6S,8S;
- 5S,6R,8R;
- 5R,6S,8R;
- and 5S,6R,8S.
6 more elements
Dependencies are inferred from the claim text.