Process for preparing indenyl acetic acids
AssigneeMerck & Co., Inc.
InventorsRobert F. Czaja, Edward J. J. Grabowski
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Abstract
This invention relates to an improved process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid.
Claims4
An improved process for the preparation of 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl-acetic acid which comprises heating an anhydrous solution of 5-fluoro-2-methyl-1-(p-methylthiobenzyl)indenylidene-3-acetic acid in contact with anhydrous hydrogen bromide, wherein the molar ratio of 5-fluoro-2-methyl-1-(p-methylthiobenzyl)indenylidene-3-acetic acid to hydrogen bromide is between 1 to 0.1 and 1 to 0.5, and the temperature is maintained between 50.degree.-100.degree. C. in a sealed container, to produce 5-fluoro-2-methyl-1-(p-methylthiobenzyledene)indenyl-3-acetic acid, and submitting said indenyl-3-acetic acid to oxidation.
In an improved process for the preparation of 5-fluoro-2-methyl-1-(p-methylthiobenzylidene)-indenyl-3-acetic acid, the improvement which comprises heating an anhydrous solution of 5-fluoro-2-methyl-1-(p-methylthiobenzyl)indenylidene-3-acetic acid in contact with anhydrous hydrogen bromide, wherein the molar ratio of 5-fluoro-2-methyl-1-(p-methylthiobenzyl)-indenylidene-3-acetic acid to hydrogen bromide is between 1 to 0.1 and 1 to 0.5, and the temperature is maintained between 50.degree.-100.degree. C. in a sealed container.
Dependencies are inferred from the claim text.