US 4,233,453 A · 15-Deoxy-16-hydroxy-16-allenyl prostane derivatives of the E and F series

Abstract

This invention disclosed herein relates to pharmacologically active 15-deoxy-16-hydroxy prostaglandin derivatives of the E and F series wherein C.sub.16 is substituted with allenyl. These compounds are active as hypotensives, antisecretory, bronchodilating and fertility control agents.

Claims4

Dependent claims

An optically active compound of the formula:

##STR15## wherein X is ##STR16## Y is:
##STR17## R.sub.1 is hydrogen or hydroxyl;
R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl;
R.sub.4 is hydrogen, C.sub.1 to C.sub.3 alkyl, or chlorine;
Z is ##STR18## wherein p is 2 to 5, and the racemic mixture thereof;
and when R.sub.1 is hydrogen, the pharmaceutically acceptable salts thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

06/046,512Filed 7 Jun 1979

Granted

11 Nov 1980

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 49/203
Unsaturated compounds containing keto groups bound to acyclic carbon atoms: with only carbon-to-carbon double bonds as unsaturation
C07C 29/42
By reaction with aldehydes or ketones: with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
C07C 45/004
Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds: by reaction with…
C07C 405/00
Compounds containing a five-membered ring having two side-chains in ortho position to

Abstract

Claims4

Dependent claims

An optically active compound of the formula:

##STR15## wherein X is ##STR16## Y is:
##STR17## R.sub.1 is hydrogen or hydroxyl;
R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl;
R.sub.4 is hydrogen, C.sub.1 to C.sub.3 alkyl, or chlorine;
Z is ##STR18## wherein p is 2 to 5, and the racemic mixture thereof;
and when R.sub.1 is hydrogen, the pharmaceutically acceptable salts thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

06/046,512Filed 7 Jun 1979

Granted

11 Nov 1980

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 49/203
Unsaturated compounds containing keto groups bound to acyclic carbon atoms: with only carbon-to-carbon double bonds as unsaturation
C07C 29/42
By reaction with aldehydes or ketones: with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
C07C 45/004
Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds: by reaction with…
C07C 405/00
Compounds containing a five-membered ring having two side-chains in ortho position to

15-Deoxy-16-hydroxy-16-allenyl prostane derivatives of the E and F series

Life of this patent

Abstract

Claims4

15-Deoxy-16-hydroxy-16-allenyl prostane derivatives of the E and F series

Life of this patent

Abstract

Claims4