1-(8-Methyl-2-phenyl(or thienyl)-8-azabicyclo[3.2.1]octan-3-yl) ethanone
AssigneeSterling Drug Inc.
InventorsRobert L. G. Clarke, Sol J. Daum
Life of this patent
Estimating the term…
Abstract
Compounds of the tropane (8-azabicyclo[3.2.1]octane) series having an aromatic substitutent in the 2-position and a carboalkoxy group in the 3-position are prepared by reacting a tropane-3-carboxylate having a double bond in the 2,3-position with an aryl Grignard reagent. Transformations of the substituent on nitrogen are subsequently effected. Compounds where the 3-carboalkoxy group is in the exo configuration possess hypoglycemic activity, and those where the 3-carboalkoxy group is in the endo configuration possess narcotic antagonist activity.
Claims3
(exo,exo)-1-(8-Methyl-2-Ar-8-azabicyclo[3.2.1]-octan-3-yl)ethanone, wherein Ar is phenyl or 2-thienyl;
- or a pharmaceutically acceptable acid-addition salt thereof.
Dependencies are inferred from the claim text.