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US 4,233,446 AGranted
5-Chloro-7,8-dihydro-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives
AssigneeAmerican Home Products Corporation
InventorsAnthony C. Scotese, Robert L. Morris, Arthur A. Santilli
Life of this patent
Estimating the term…
Abstract
7-Chloro-7,8-dihydro-7-oxo-pyrido[2,3]-d]pyrimidine-6-carboxylic acid derivatives are intermediates useful for the production of 7,8-dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]-pyrimidine-6-carboxyl ic acid derivatives which in turn are gastric anti-secretory agents for treatment of peptic ulcer disease and generally anti-allergic agents useful in the treatment of atopic immediate hypersensitivity reactions.
Claims4
A compound of the formula:
- ##STR14## in which R.sup.2 is hydrogen, hydroxy, alkyl of 1 to 6 carbon atoms, alkylthio of 1 to 6 carbon atoms, phenyl, 4-methoxyphenyl, 4-chlorophenyl, 1-pyrrolidinyl or methylphenylamino;
- R.sup.6 is alkoxy of 1 to 6 carbon atoms;
- and
- R.sup.8 is hydrogen, alkyl of 1 to 6 carbon atoms, 2-alkoxyethyl of 3 to 6 carbon atoms, allyl, propargyl, phenyl, 4-methoxyphenyl, 4-chlorophenyl, benzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-(4-morpholinyl)-phenyl or piperonyl.
1 more element
Dependencies are inferred from the claim text.