Back to results
US 4,233,315 AGranted
Analgesic potentiation
AssigneeMcNeilab, Inc.
InventorJoseph F. Gardocki
Life of this patent
Estimating the term…
Abstract
A method of producing analgesia by administering m-benzoylhydratropic acid or a salt thereof together with acetaminophen and compositions therefor.
Claims8
A pharmaceutical composition suitable for reducing pain in dosage unit form comprising an effective antinociceptive amount in combination of
- (1) as primary antinociceptive agent, from about 12 to 50 milligrams of a m-benzoylhydratropic acid compound selected from the group consisting of (a) m-benzoylhydratropic acid having the formula ##STR2## and (b) the non-toxic therapeutically acceptable salts thereof, and (2) as potentiating agent, from about 170 to 450 milligrams of acetaminophen;
- wherein said primary and said potentiating agent are in admixture with a pharmaceutically acceptable carrier.
A method for producing analgesia which comprises orally administering to a subject suffering from pain
- (1) as primary active agent from about 0.2 to 0.83 mg/kg of body weight of a m-benzoylhydratropic acid compound selected from the group consisting of (a) m-benzoylhydratropic acid having the formula ##STR3## and (b) the non-toxic therapeutically acceptable salts thereof, and (2) as potentiating agent from about 2.8 to 7.5 mg/kg body weight of acetaminophen.
A method for producing analgesia which comprises orally administering to a subject suffering from pain
- (1) as primary active agent from about 12 to 50 milligrams of a m-benzoylhydratropic acid compound selected from the group consisting of (a) m-benzoylhydratropic acid having the formula ##STR4## and (b) the non-toxic therapeutically acceptable salts thereof, and (2) as potentiating agent from about 170 to 450 milligrams of acetaminophen.
Dependencies are inferred from the claim text.