Antimicrobial agents and their use
AssigneeBayer Aktiengesellschaft
InventorsWolfgang Kramer, Karl H. Buchel, Manfred Plempel, Ingo Haller
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Abstract
The invention involves the provision of compositions containing a 3,3-dialkyl- or 3-aryl-phenoxy-1-(1,2,4-triazol-1-yl)- and (imidazol-1-yl-alkan-2-ol) ethers which are particularly effective as antimicrobial especially antimycotic, agents. The invention also includes use of said compositions for providing antimicrobial, particularly antimycotic effect.
Claims14
A pharmaceutical composition containing as an active ingredient on antimycotically effective amount of a compound which is an azolyl ether of the following formula, or its salt or a metal complex thereof ##STR93## in which A is a CH group,
- R is alkyl, alkenyl or alkinyl, each having up to 4 carbon atoms, phenyl or benzyl, each being optionally mono- or poly-substituted by halogen, cyano, nitro, alkyl having from 1 to 4 carbon atoms, alkoxy-carbonyl having from 1 to 4 carbon atoms in the alkyl moiety, and halogenoalkyl having up to 2 carbon atoms and up to 3 halogen atoms,
- X is halogen, alkyl, alkoxy, alkylthio, alkylsulphonyl, halogenoalkyl or alkoxycarbonyl, each having up to 4 carbon atoms in the alkyl moiety, nitro, cyano, or phenyl, phenoxy or phenylthio, each optionally substituted by halogen, cyano, nitro or halogenoalkyl having up to 2 carbon atoms and up to 3 halogen atoms,
- Y is a straight-chain or branched alkyl having from 1 to 9 carbon atoms and optionally mono- or poly-substituted by halogen, hydroxyl, cyano, --CO--OR.sup.1 wherein R.sup.1 is alkyl having from 1 to 4 carbon atoms, --CO--NR.sup.2 R.sup.3 wherein R.sup.2 and R.sup.3 are the same or different and each is hydrogen, alkyl having from 1 to 4 carbon atoms, or phenyl optionally substituted by halogen, --O--CO--R.sup.4 wherein R.sup.4 is alkyl having from 1 to 18 carbon atoms, halogenoalkyl having from 1 to 4 carbon atoms and from 1 to 3 halogen atoms, phenyl or benzyl each optionally mono- or poly-substituted by halogen or cycloalkyl having 5 or 6 carbon atoms;
- or phenyl optionally mono- or poly-substituted by halogen, and
- n represents an integer having a value of from 0 to 5, in admixture with a solid, liquid or liquefied gaseous diluent.
Dependencies are inferred from the claim text.