Novel derivatives of 2-(4-quinolinylamino)-5-fluoro-benzoic acids
AssigneeRoussel Uclaf
InventorsAndre Allais, Jean Meier, Roger Deraedt
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Abstract
Derivatives of 2-(4-quinolinylamino)-5-fluorobenzoic acid compounds of the formula ##STR1## wherein X is selected from the group consisting of chlorine and --CF.sub.3 in the 7- or 8-position and R is selected from the group consisting of hydrogen, an esterifying group, alkali metals, alkaline earth metals, ammonium and non-toxic, pharmaceutically acceptable organic amines and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable analgesic properties and their preparation.
Claims21
A compound selected from the group consisting of 2-(4-quinolinylamino)-5-fluoro-benzoic acid compounds of the formula ##STR18## wherein X is selected from the group consisting of chlorine and --CF.sub.3 in the 7- or 8-position and R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbons, ##STR19## wherein A is branched alkylene of 3 to 5 carbon atoms or --(CH.sub.2).sub.n -- and n is a number of 2 to 5 and R.sub.1 and R.sub.2 are individually alkyl of 1 to 8 carbon atoms or together with the nitrogen atom to which they are attached form a heterocyclic selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl and N-piperazinyl optionally substituted on the second nitrogen atoms with alkyl of 1 to 4 carbon atoms, ##STR20## with R.sub.3 being selected from the group consisting of hydrogen, halogen, --CF.sub.3, --SCF.sub.3, --OCF.sub.3 and alkyl and alkoxy of 1 to 8 carbon atoms in the 2,3- or 4-position, n' is 2 to 5 and ##STR21## and R.sub.4 and R.sub.5 are both hydrogen or form a ketonide of the formula ##STR22## and P and Q are alkyl of 1 to 8 carbon atoms, phenylalkyl of 7 to 13 carbon atoms or phenyl, alkali metals, alkaline earth metals, ammonium and non-toxic, pharmaceutically acceptable organic amines and their non-toxic, pharmaceutically acceptable acid addition salts.
Dependencies are inferred from the claim text.