Amine derivatives and pharmaceutical compositions containing them

A compound of the formula (II) ##STR40## or a physiologically acceptable salt, N-oxide or hydrate thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl;

• R.sub.1, R.sub.2, R.sub.5 and R.sub.6, which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl, lower alkyl interrupted by an oxygen atom, or lower alkyl interrupted by a group ##STR41## where R.sub.4 represents hydrogen or lower alkyl or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a pyrrolidine or piperidine ring;
• Q represents a furan ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions;
• Q' represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3-positions;
• X and E which may be the same or different, each represent --CH.sub.2 --, --O-- or --S--;
• n and p, which may be the same or different, each represent zero, 1 or 2;
• m and q, which may be the same or different, each represent 2, 3 or 4;
• Alk and Alk', which may be the same or different, each represent a straight chain alkylene group of 1 to 3 carbon atoms;
• except that n is not zero when X is oxygen and p is not zero when E is oxygen and Q' is a furan or thiophen ring system.

A compound of the formula (III) ##STR42## or a physiologically acceptable salt, N-oxide or hydrate thereof, in which Y represents .dbd.O, .dbd.S, .dbd.CHNO.sub.2 or =NR.sub.3 where R.sub.3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl;

• R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl, lower alkyl interrupted by an oxygen atom, lower alkyl interrupted by ##STR43## in which R.sub.4 represents hydrogen or lower alkyl;
• or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a pyrrolidine or piperidine ring;
• Q represents a furan ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions;
• X represents --CH.sub.2 --, --O-- or --S--;
• n represents zero or 1 except that n is not zero when X is oxygen;
• m represents 2, 3 or 4;
• Alk represents a straight chain alkylene group of 1 to 3 carbon atoms;
• q represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -- group;
• p represents zero, 1 or 2;
• E represents --CH.sub.2 --, --O--, or --S--;
• and
• Z' represents a phenyl ring optionally substituted by at least one of lower alkyl, hydroxy, lower alkyl hydroxy, amino, lower alkoxy or halo or a furyl, thienyl, pyridyl, imidazolyl, thiazolidinyl, oxazolidinyl or pyrimidyl ring optionally substituted by lower alkyl optionally substituted by hydroxy or halo;
• except that p is not zero when E is oxygen and Z is furyl or thienyl.