Mercaptocarboxylic acid radiopharmaceuticals
AssigneeMedi-Physics, Inc.
InventorsHarry S. Winchell, Tz-Hong Lin
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Abstract
Mercaptocarboxylic acid chelated heavy metal radioisotope pharmaceuticals and methods for making them.
Claims9
A radiopharmaceutical comprising a complex of a mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least one mercapto group with a radioactive heavy metal ion produced by reduction with stannous chloride in the presence of the chelating agent wherein said complex is formed at a pH of from about 2 to 4 and the mole ratio of said metal chelating agent to stannous chloride present to reduce such metal ion is about three to one.
A reagent for producing a radiopharmaceutical comprising an aqueous solution containing mercaptocarboxylic acid chelating agent having at least one carboxylic acid group and at least mercapto group, 99-m-technetium pertechnetate and stannous chloride, where the mole ratio of said chelating agent to stannous chloride is about 3 to 1 and the pH of said solution being from about 2 to about 4.
A method of imaging the renal cortex, brain abnormalities, tumors and myocardial infarcts of a patient comprising intravenously injecting said patient with a radiopharmaceutical comprising a complex of a mercaptocarboxylic acid metal chelating agent with a radioactive heavy metal ion produced by reduction with stannous chloride, wherein said complex is formed at a pH of from 2 to 4 and the mol ratio of said metal chelating agent to stannous chloride present to produce metal ion is about three to one, and scanning with a suitable apparatus.
Dependencies are inferred from the claim text.