Stabilized radiographic scanning agents
AssigneeThe Procter & Gamble Company
InventorMahdi B. Fawzi
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Abstract
Stable compositions, useful as technetium-99m-based scintigraphic agents, comprise gentisic acid or a pharmaceutically-acceptable salt or ester thereof in combination with a pertechnetate reducing agent or dissolved in pertechnetate-99m (.sup.99m TcO.sub.4.sup.-) solution. The compositions are especially useful in combination with a phosphate or phosphonate material which carries the radionuclide to bone, thus providing a skeletal imaging agent.
Claims22
A stable composition, useful in the preparation of technetium-99m-based radiographic scanning agents, comprising:
- a pertechnetate reducing agent;
- and a stabilizing amount of a gentisate stabilizer selected from gentisic acid and the soluble, pharmaceutically-acceptable salts and esters thereof.
A composition useful in the preparation of technetium-99m-based radiographic scanning agents, comprising:
- and oxidized pertechnetate solution having dissolved therein a stabilizing amount of a gentisate stabilizer selected from gentisic acid or a pharmaceutically-acceptable salt or ester thereof.
A method of preparing a stabilized technetium-99m-based scanning agent, comprising codissolving a stabilizing amount of a gentisate stabilizer selected from gentisic acid or a pharmaceutically-acceptable salt or ester thereof with an aqueous solution of radioactive technetium in the +3, +4 or +5 valence state.
Dependencies are inferred from the claim text.