Coriolin derivatives
AssigneeNippon Kayaku Kabushiki Kaisha
InventorsYuya Nakayama, Mamoru Kunishima, Akira Matsuda, Tomio Takeuchi
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Abstract
Anti-tumor low-toxicity coriolin derivatives represented by the following general formula: ##STR1## wherein one of X and Y is ##STR2## and the other is >C OH, >C.dbd.O or ##STR3##
Claims6
A coriolin derivative represented by the general formula:
- ##STR18## wherein one of X and Y is ##STR19## and the other is >C OH,>C.dbd.O or ##STR20##
1.alpha.-octanoyl-4.beta.,15:6.beta.,7.beta.-dioxide-5.beta.-hydroxy-8(2 2 -methylene-21-butanolide)hirsutane.
1.alpha.-octanoyl-4.beta.,15:6.b eta.,7.beta.-dioxide-5-oxo-8(22-methylene-21-butanolide)hirsutane.
1.alpha.-octanoyl-4.beta.,15:6.beta.,7.beta.-dioxide-5(19-methy lene-18-butanolide)-8.beta.-hydroxy-hirsutane.
1.alpha.-octanoyl-4.beta.,15:6.beta.,7.beta .-dioxide-5(19-methylene-18-butanolide)-8-oxo-hirsutane.
1.alpha.-octanoyl-4.beta.,15:6.beta.,7.beta.-dioxide- 5(19-methylene-18-butanolide)-8(22-methylene-21-butanolide)hirsutane.
Dependencies are inferred from the claim text.