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AssigneeChinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
InventorsEniko Szebenyi nee Gyori, Vera Kovacs nee Mindler, Laszlo Redey, Agnes Szemos nee Szonyi
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The invention concerns a new process for the preparation of 5-halo-6,9.alpha.-oxido-prostaglandin derivatives of the general formula II ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group optionally substituted by aryl, amino, hydroxyl or a halogen atom, an equivalent of a pharmaceutically acceptable organic or inorganic cation or a conventional hydroxyl protecting group; R.sup.2 represents a hydrogen atom, a hydroxyl group or a conventionally protected hydroxyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4 represents a hydrogen atom or a conventional hydroxyl protecting group; R.sup.5 stands for a straight or branched chained alkyl group, optionally containing hetero atom(s) and optionally substituted by a substituted or unsubstituted aryl group, and X stands for a halogen atom, which comprises subsjecting prostaglandin F.sub.2.alpha. derivatives of the general formula I ##STR2##
A process for the preparation of a 5-halo-6,9.alpha.-oxido-prostaglandin derivative of the formula II ##STR6## wherein R.sup.1 is hydrogen alkyl which can be substituted with aryl, amino, hydroxyl or halogen, a pharmaceutically acceptable organic or inorganic cation or a conventional hydroxyl protecting group;
A process for the preparation of a 5-halo-6,9.alpha.-oxido-prostaglandin derivative of the formula ##STR8## wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.20 straight or branched alkyl which can be substituted with amino, hydroxyl or halogen, or a pharmaceutically acceptable organic or inorganic cation;
A process for the preparation of a 5-halo-6,9.alpha.-oxido-prostaglandin derivative of the formula ##STR10## wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.2 straight or branched alkyl which can be substituted with amino, hydroxyl or halogen, a pharmaceutically acceptable organic or inorganic cation or a hydroxyl protecting group selected from the group which consists of tetrahydro pyranyl, alkylsilyl, aromatic or aliphatic acyl or aromatic carbamoyl eliminated by hydrolysis;
Dependencies are inferred from the claim text.