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US 4,233,030 AGranted
Methods and apparatus for liquid chromatography
AssigneeNational Research Development Corporation
InventorsPeter J. Twitchett, Peter L. Williams
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AssigneeNational Research Development Corporation
InventorsPeter J. Twitchett, Peter L. Williams
Estimating the term…
The eluent from a liquid chromatography column is irradiated, while flowing between the column and a conventional detector adapted to detect a given property, in order to convert a known or suspected constituent photochemically to a species which possesses the property or to one in which the property is changed in magnitude (enhanced or reduced) to a substantial degree. The irradiation may be by UV or visible light, and the property may eg be fluorescence with, or absorbance of, UV or visible light. The method can increase the sensitivity and/or selectivity of detection, eg in the presence of interfering substances which do not react to irradiation in the same way as the constituent of interest. Apparatus for performing the method may comprise a long translucent small-bore tube shaped to a configuration which surrounds a light-source and which is connected between the column and the detector.
A method of high pressure liquid chromatography wherein the eluent from a chromatographic column enters a detector adapted to detect a known or suspected constituent by means of an optical property, wherein the eluent while flowing between the column and the detector is irradiated in order to convert the constituent photochemically to a species which possesses this property or in which said property is changed in magnitude to a substantial degree.
Apparatus for high pressure liquid chromatography in which there is connected between a chromatographic column and a detector arranged to receive eluent from the column a photochemical reactor comprising a translucent duct for passage of the eluent and a light-source arranged to irradiate the eluent flowing in the duct.
A method of identifying in an eluent sample from a high-pressure liquid chromatograph column a constituent chosen from the group consisting of lysergic acid diethylamide (LSD) and cannabinol (CBN) comprising:
Dependencies are inferred from the claim text.