2-Substituted-1-alkyl-nitroimidazoles
AssigneeBASF SE
InventorsHelmut Hagen, Rolf-Dieter Kohler
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Abstract
Novel 2-substituted 1-alkyl-nitroimidazoles and a process for their preparation by reaction of 2-methyl-nitroimidazoles with oxalic acid diesters, followed by reaction of the resulting nitroimidazol-2-yl-pyruvic acid esters with chlorine, in turn followed, if desired, by reaction of the resulting 2-dihalomethyl-nitroimidazoles with water. Both the novel and the known compounds obtainable by the process of the invention are valuable starting materials for the preparation of dyes, pesticides and drugs.
Claims2
A 2-substituted 1-alkyl-5-nitroimidazole of the formula ##STR16## where R.sup.1 is an alkyl group of 1 to 7 carbon atoms, one R.sup.2 is nitro and the other R.sup.2 is an alkyl group of 1 to 7 carbon atoms or hydrogen, R.sup.3 is ##STR17## and X is halogen, wherein the R.sup.2 attached to the carbon in the 5 position is nitro and wherein R.sup.1 and R.sup.2 are either unsubstituted or substituted by an alkyl group of 1 to 4 carbon atoms or nitro.
2-Dichloromethyl-1-methyl-5-nitroimidazole.
Dependencies are inferred from the claim text.