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US 4,232,157 AGranted
Process for preparing lysergol derivatives
OwnerCorvi M. Enricoinventor
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Abstract
A novel process is disclosed for the preparation of derivatives of lysergol having the general formula: ##STR1## According to this process lysergol is directly used as the starting compound and, after the methylation at the 1 position of the corresponding 10 alpha-methoxy-lumilysergol, the methylated compound is directly esterified with a carboxylic acid R--COOH, the acid being selected in the group comprising aliphatic, cycloaliphatic, aromatic, and heterocyclic carboxylic acids, containing up to 10 carbon atoms.
Claims7
A process for preparing a compound of the formula:
- ##STR9## wherein R is the radical of an organic carboxylic acid selected from the group consisting of nicotinic acid, 5-bromo-nitocinic acid and 2-furoic acid, said process comprising:
- (a) converting lysergol, having the formula:
- ##STR10## to 10-alpha-methoxy-lumilysergol of the formula:
- ##STR11## by irradiation with U. V. rays:
- (b) methylating the compound (X) at the indole nitrogen atom by means of a methylating agent to obtain the 1-methyl derivative of the formula:
- ##STR12## (c) reacting the alcohol (XI) with a molar excess of an organic carboxylic acid of the formula R--COOH, wherein R is defined above, to obtain the compound (I).
3 more elements
Dependencies are inferred from the claim text.