Compositions for and a method of preventing diabetic complications
AssigneeSyntex (U.S.A.) Inc.
InventorL. David Waterbury
Life of this patent
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Abstract
Compositions containing and methods of employing as the essential ingredients substituted xanthone carboxylic acid compounds which are useful in the prevention of complications of diabetes. Methods for preparing these compounds and the compositions and intermediates therein are also disclosed.
Claims25
A method for preventing or relieving diabetes mellitus-associated complications chosen from the group consisting of cataracts, retinopathy, and neuropathy in a diabetic mammal, which method comprises topically administering to said mammal an alleviating or prophylactic amount of a compound of the formula ##STR20## and pharmaceutically acceptable non-toxic C.sub.1 to C.sub.6 linear or branched alkyl esters, C.sub.1 to C.sub.6 linear or branched alkyl amides or salts thereof where R is selected from the group hydrogen, R.sup.1 (O).sub.n S-- where R.sup.1 is C.sub.1 to C.sub.6 linear or branched alkyl when n is the integer 0 or 1, C.sub.1 to C.sub.6 linear or branched hydroxyalkyl, di- C.sub.1 to C.sub.6 linear or branched alkylamino, the alkyl group optionally substituted with hydroxy when n is the integer 2 or hydrogen when n is the integer 3;
- R.sup.4 C(O)-- where R.sup.4 is C.sub.1 to C.sub.6 linear or branched alkyl or C.sub.5 to C.sub.10 carbocyclic alkyl;
- and C.sub.1 to C.sub.6 linear or branched alkoxy optionally substituted with at least one hydroxy and R' is selected from the group consisting of hydrogen, C.sub.1 to C.sub.10 linear or branched alkyl, C.sub.1 to C.sub.10 linear or branched alkoxy, C.sub.1 to C.sub.10 linear or branched thioalkyl and the radical R.sup.3 SO-- where R.sup.3 is C.sub.1 to C.sub.6 linear or branched alkyl.
A method for preventing or relieving diabetes mellitus-associated complications chosen from the group consisting of cataracts, retinopathy, nephropathy and neuropathy in a diabetic mammal, which method comprises orally administering to said mammal an alleviating or prophylactic amount of a compound of the formula ##STR21## and pharmaceutically acceptable non-toxic C.sub.1 to C.sub.6 linear or branched alkyl esters, C.sub.1 to C.sub.6 linear or branched alkyl amides or salts thereof where R is selected from the group hydrogen, R.sup.1 (O).sub.n S-- where R.sup.1 is C.sub.1 to C.sub.6 linear or branched alkyl when n is the integer 0 or 1, C.sub.1 to C.sub.6 linear or branched hydroxyalkyl, di- C.sub.1 to C.sub.6 linear or branched alkylamino, the alkyl group optionally substituted with hydroxy when n is the integer 2 or hydrogen when n is the integer 3;
- R.sup.4 C(O)-- where R.sup.4 is C.sub.1 to C.sub.6 linear or branched alkyl or C.sub.5 to C.sub.10 carbocyclic alkyl;
- and C.sub.1 to C.sub.6 linear or branched alkoxy optionally substituted with at least one hydroxy and R' is selected from the group consisting of hydrogen, C.sub.1 to C.sub.10 linear or branched alkyl, C.sub.1 to C.sub.10 linear or branched alkoxy, C.sub.1 to C.sub.10 linear or branched thioalkyl and the radical R.sup.3 SO-- where R.sup.3 is C.sub.1 to C.sub.6 linear or branched alkyl.
Dependencies are inferred from the claim text.