Process for preparation of piperidyl-indoles
AssigneeRoussel Uclaf
InventorsClaude Dumont, Jacques Guillaume, Lucien Nedelec
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Abstract
A novel process for the preparation of piperidylindoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms and X is selected from the group consisting of hydrogen, nitro, fluorine, bromine, chlorine and alkoxy of 1 to 3 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts thereof by reacting an indole of the formula ##STR2## with 4-piperidone hydrochloride in an alkaline medium to obtain the compound of formula I which is optionally salified and the novel product, 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts.
Claims6
A process for the preparation of piperidyl-indoles of the formula ##STR6## wherein X is selected from the group consisting of hydrogen, fluorine, chlorine, bromine, alkoxy of 1 to 3 carbon atoms and nitro and R is selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms comprising reacting an indole of the formula ##STR7## with 4-piperidone hydrochloride in an alkaline medium to form the compound of formula I and optionally salifying the latter to obtain its acid addition salt.
A compound selected from the group consisting of 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts.
A composition having antidepressive, antiemetic and antiparkinsonian activity comprising an effective amount of 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts and an inert pharmaceutical carrier.
A method of treating psychic disorders in warm-blooded animals comprising administering to warm-blooded animals an amount of 5-nitro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole and its non-toxic, pharmaceutically acceptable acid addition salts sufficient to relieve psychic disorders.
Dependencies are inferred from the claim text.