1-Hydroxyimidazole-5-methanamine derivatives
AssigneeAmerican Home Products Corporation
InventorsAdolf H. Philipp, Ivo L. Jirkovsky
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Abstract
1-Hydroxyimidazole-5-methanamine derivatives characterized by having a lower alkyl group at positions N, N and 5 of the latter derivatives as well as having various substituents at position 2 of the imidazole ring are disclosed. These derivatives are useful as antihypertensive agents in a mammal. Methods for their preparation, use and pharmaceutical compositions also are disclosed.
Claims27
A compound of formula I ##STR5## in which R.sup.1, R.sup.2 and R.sup.3 each is lower alkyl, or R.sup.1 is lower alkyl and R.sup.2 and R.sup.3 together form a chain of formula --C(.dbd.NOH)--CH.sub.2 -- wherein the --CH.sub.2 -- is joined to the nitrogen, and R.sup.4 is lower alkyl, 1-naphthalenyl, 2-, 3- or 4-pyridinyl, 2- or 3-furyl, 2- or 3-thieny, phenyl or phenyl mono-, di- or trisubstituted with halo, lower alkyl, lower alkoxy, hydroxy, or trifluoromethyl, or a therapeutically acceptable acid addition salt thereof.
A pharmaceutical composition comprising a compound of formula I, or a therapeutically acceptable acid addition salt thereof, and a diuretic and/or antihypertensive agent.
Dependencies are inferred from the claim text.