1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives

Abstract

1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives are provided having the structure ##STR1## wherein (CH.sub.2).sub.n represents a straight chain alkylene group containing 2 to 5 carbons, and R.sub.1 and R.sub.2 are the same or different and may be hydrogen or lower alkyl with the proviso that at least one of R.sub.1 and R.sub.2 is lower alkyl, or ##STR2## can be taken together to form a heterocyclic radical containing 5- or 6-members in the heterocyclic ring, such as pyrrolidino, piperidino or morpholino, and R.sub.3 and R.sub.4 may be the same or different and are hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and physiologically acceptable acid addition salts thereof. These compounds are useful as anti-inflammatory agents. A pharmaceutical composition containing the above compounds and a method of use are also provided.

Dependencies are inferred from the claim text.