Novel soluble derivatives of 2,4-diamino pyrimidine
OwnerPierre R. Dick, Max Rombiinventors
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Abstract
The novel derivatives correspond to the general formula II: ##STR1## in which: R.sub.1 R.sub.2 R.sub.3 and R.sub.4 represent identical or different groups which can each be a hydrogen or halogen atom or an alkyl group, alkoxy, or benzyloxy group and R is the residue of an R--CHO aldehyde selected from among linear or branched saturated aliphatic aldehydes including 1 to 4 carbon atoms or again represents the Z--CH.dbd.CH radical in which Z represents a hydrogen atom, a linear or branched saturated alkyl group, an aromatic nucleus or an aromatic heterocyclic nucleus or again R represents the radical HO CH.sub.2 (CH OH)n--in which n has the value of 3 or 4. The novel compounds have high solubility in water and antibacterial activity and potentiating power.
Claims15
Derivatives of 2,4-diamino pyrimidine corresponding to the general formula II:
- ##STR4## in which:
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently represent a hydrogen atom, a halogen atom, a methyl group, a methoxy group or a benzyloxy group;
- and,
- R is the radical of a R--CHO aldehyde wherein R represents hydrogen or an alkyl group containing from 1 to 3 carbon atoms, the Z--CH.dbd.CH radical wherein Z represents a hydrogen atom or a benzene ring;
- or
- R represents the radical HO--CH.sub.2 --(CHOH).sub.n -- in which n has the value 3 or 4.
Derivatives of 2,4-diamino pyrimidine selected from the group consisting of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine N.sub.4 ethane sulfonic acid (or its sodium salt);
- 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine N.sub.4 methane sulfonic acid (or its sodium salt);
- 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine N.sub.4 glucose sulfonic acid (or its sodium salt);
- 2,4-diamino-5-(3',4'-dimethoxybenzyl)pyrimidine N.sub.4 ethane sulfonic acid (or its sodium salt);
- 2,4-diamino-5-(3',4'-dimethoxybenzyl)pyrimidine N.sub.4 glucose sulfonic acid (or its sodium salt);
- 2,4-diamino-5-(3',4'-dimethoxybenzyl)pyrimidine methane sulfonic acid (or its sodium salt);
- 2,4-diamino-5-(2'-methyl-4',5'-dimethoxybenzyl)pyrimidine N.sub.4 methane sulfonic acid (or its sodium salt) and 2,4-diamino-5-(2'-methyl-4',5'-dimethoxybenzyl)pyrimidine N.sub.4 isobutane sulfonic acid (or its sodium salt).
Dependencies are inferred from the claim text.