Heterocyclic compounds
AssigneeBeecham Group Limited
InventorRoger J. Ponsford
Life of this patent
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Abstract
This invention relates to pyrimidine derivatives for treating material and bacterical infestions in humans and animals.
Claims54
A pharmaceutical composition for treating malarial and bacterial infections in humans and animals which comprises an antimalarially or antibacterially effective amount of a compound of the formula (II):
- ##STR10## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, methyl or ethyl;
- X is alkylene of 1 to 10 carbon atoms;
- Y is O or S.;
- and Ar is phenyl, naphthyl, anthranyl, phenanthryl or phenyl substituted by from 1 to 5 substituents selected from the group consisting of fluorine, chlorine, bromine, lower alkoxyl, lower acyloxyl, lower alkyl, lower alkenyl, cycloalkyl of 5 or 6 carbon atoms, cycloalkenyl of 5 or 6 carbon atoms and lower alkylthio;
- in combination with a pharmaceutically acceptable carrier.
A pharmaceutical composition for treating malarial and bacterial infections in humans and animals which comprises an antimalarially or antibacterially effective amount of a compound of the formula:
- ##STR14## or a pharmaceutically acceptable acid addition salt thereof, wherein Ar.degree. and n have the following values:
- ______________________________________ Ar.degree. n ______________________________________ pentachlorophenoxy 3 2,3,4,6-tetrachlorophenoxy 3 2,4,6-trichlorophenoxy 3 2,4-dichlorophenoxy 3 2,3-dichlorophenoxy 3 2-(prop-2-enyl)-4-bromophenoxy 3 2-bromophenoxy 3 2-(prop-2-enyl)-4-methoxyphenoxy 3 3,4,5-trimethoxyphenoxy 3 3,4,5-trimethoxyphenoxy 4 2,6-dimethoxyphenoxy 3 2,6-dimethoxyphenoxy 2 2,3-dimethoxyphenoxy 3 phenoxy 4 phenoxy 6 2,4,6-trichlorophenoxy 4 2,4,5-trichlorophenoxy 6 phenoxy 8 4-methoxyphenoxy 8 phenoxy 10 2-chlorophenoxy 10 2,6-dimethoxyphenoxy 10 ______________________________________
- in combination with a pharmaceutically acceptable carrier.
A pharmaceutical composition for treating malarial and bacterial infections in humans and animals which comprises an antimalarially or antibacterially effective amount of a compound of the formula:
- ##STR15## wherein Ar.degree. and n have the following values:
- ______________________________________ Ar.degree. n ______________________________________ pentachlorophenoxy 3 phenoxy 10 ______________________________________
- in combination with a pharmaceutically acceptable carrier.
A method of treating malarial and bacterial infections in humans and animals which comprises administering to a human or animal in need of such treatment an antimalarially or antibacterially effective amount of a compound of the formula (II):
- ##STR16## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen, methyl or ethyl;
- X is alkylene of 1 to 10 carbon atoms;
- Y is O or S;
- and Ar is phenyl, naphthyl, anthranyl, phenanthryl or phenyl substituted by from 1 to 5 substituents selected from the group consisting of fluorine, chlorine, bromine, lower alkoxyl, lower acyloxyl, lower alkyl, lower alkenyl, cycloalkyl of 5 or 6 carbon atoms, cycloalkenyl of 5 or 6 carbon atoms and lower alkylthio.
A method of treating malarial and bacterial infections in humans and animals which comprises administering to a human or animal in need of such treatment an antimalarially or antibacterially effective amount of a compound of the formula:
- ##STR20## or a pharmaceutically acceptable acid addition salt thereof, wherein Ar.degree. and n have the following values:
- ______________________________________ Ar.degree. n ______________________________________ pentachlorophenoxy 3 2,3,4,6-tetrachlorophenoxy 3 2,4,6-trichlorophenoxy 3 2,4-dichlorophenoxy 3 2,3-dichlorophenoxy 3 2-(prop-2-enyl)-4-bromophenoxy 3 2-bromophenoxy 3 2-(prop-2-enyl)-4-methoxyphenoxy 3 3,4,5-trimethoxyphenoxy 3 3,4,5-trimethoxyphenoxy 4 2,6-dimethoxyphenoxy 3 2,6-dimethoxyphenoxy 2 2,3-dimethoxyphenoxy 3 phenoxy 4 phenoxy 6 2,4,6-trichlorophenoxy 4 2,4,5-trichlorophenoxy 6 phenoxy 8 4-methoxyphenoxy 8 phenoxy 10 2-chlorophenoxy 10 2,6-dimethoxyphenoxy 10 ______________________________________
A method of treating malarial and bacterial infections in humans and animals which comprises administering to a human or animal in need of such treatment an antimalarially or antibacterially effect amount of a compound of the formula:
- ##STR21## or a pharmaceutically acceptable acid addition salt thereof, wherein Ar.degree. and n have the following values:
- ______________________________________ Ar.degree. n ______________________________________ pentachlorophenoxy 3 phenoxy 10 ______________________________________
Dependencies are inferred from the claim text.