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US 4,232,018 AGranted
Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
AssigneePfizer Inc.
InventorMichael R. Johnson
Life of this patent
Estimating the term…
Abstract
Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans useful as analgesic agents, derivatives thereof, intermediates therefor and processes for their preparation.
Claims10
A compund selected from the group consisting of those having the formula ##STR7## wherein R is selected from the group consisting of hydrogen and alkanoyl having from one to five carbon atoms;
- R.sub.1 is --CO--(CH.sub.2).sub.p --NR.sub.4 R.sub.5 wherein p is 0 or an integer from 1 to 4;
- R.sub.4 and R.sub.5 taken together with the nitrogen to which they are attached represent morpholino;
- each of R.sub.2 and R.sub.3 is selected from the group consisting of hydrogen and methyl;
- Z is selected from the group consisting of
- (a) alkylene having from one to ten carbon atoms;
- (b) --(alk.sub.1).sub.m --O--(alk.sub.2).sub.n -- wherein each of (alk.sub.1) and (alk.sub.2) is alkylene having from one to ten carbon atoms, with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than ten;
- each of m and n is 0 or 1;
- and
- W is selected from the group consisting of hydrogen and ##STR8## wherein W.sub.1 is selected from the group consisting of hydrogen, fluoro and chloro;
- with the proviso that when W is hydrogen, Z is (alk.sub.1).sub.m --O--(alk.sub.2).sub.n --;
- and the pharmaceutically-acceptable acid addition salts thereof.
8 more elements
Dependencies are inferred from the claim text.