US 4,232,012 A · Composition

Abstract

There is described a pharmaceutical composition comprising one or more of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol; 5-(2-hydroxy-propoxy)-8-propyl-chromone-2-carboxylic acid; 6,7,8,9-tetrahydro-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylic acid; 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carb oxylic acid; or a pharmaceutically acceptable salt of any one thereof, in combination with one or more of aspirin, indomethacin, phenylbutazone or oxyphenbutazone. (Mixtures of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, with aspirin or indomethacin do not form part of the invention). There are also described packages containing the separate components of the composition and pharmaceutical formulations containing the composition.

Claims14

Dependent claims

A pharmaceutical composition adapted for oesophageal administration to a mammal comprising, as active ingredient, at least one chromone compound selected from 5-(2-hydroxypropoxy)-8-propyl-chromone-2-carboxylic acid;

6,7,8,9-tetrahydro-4-oxo-10-propyl-4H-naphtho-[2,3,-b]-pyran-2-carboxylic acid;
6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho[2,3,-b]pyran-2-car boxylic acid or a pharmaceutically acceptable salt of any one thereof, in combination with an anti-inflammatory selected from aspirin, indomethacin, and mixtures thereof, said composition containing 0.004 to 1200 parts by weight of said anti-inflammatory per part of said active ingredient.

Dependencies are inferred from the claim text.

Facts

Application

06/012,327Filed 15 Feb 1979 · division

Priority

GB 2872/7725 Jan 1977

Granted

4 Nov 1980

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/405
Indoles, e.g. pindolol: indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A61K 9/209
Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat: containing drug in at least two layers or in the core and in at…
A61K 31/415
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2-Diazoles
A61K 31/60
Medicinal preparations containing organic active ingredients: salicylic acid; Derivatives thereof

Family

Serial742,750Parent of this continuation-in-part · filed 18 Nov 1976

Serial863,859Parent of this division · filed 23 Dec 1977

US 4,151,292 AParent of this division

US 4,066,756 AParent of this continuation-in-part

US 4,232,012 AThis patent

From the US filing history. Foreign family members aren’t listed.

Composition

Life of this patent

Composition

Life of this patent

Abstract

Claims14