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US 4,232,010 AGranted
Calcium-antagonistic composition
AssigneeKanebo, Ltd.
InventorsGoro Tsukamoto, Koichiro Yoshino, Tominori Morita, Takashi Nose, Mitsuo Okazaki
Life of this patent
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Abstract
A phosphonic acid ester of the formula: ##STR1## and R is a lower alkyl, exhibits a calcium-antagonistic activity. Pharmaceutical compositions containing the same are useful in prophylaxis and treatment of ischemic heart diseases such as angina pectoris, myocardial, infarction, etc. and hypertension.
Claims12
A calcium-antagonistic pharmaceutical composition comprising a therapeutically effective amount of a phosphonate of the formula:
- ##STR3## and R is C.sub.1 -C.sub.4 alkyl, in combination with a pharmaceutically acceptable, non-toxic inert carrier.
Dependencies are inferred from the claim text.