Ureylene phenylene anionic naphthalenesulfonic acids
AssigneeAmerican Cyanamid Company
InventorsGerald J. Siuta, Ransom B. Conrow, John F. Poletto, Seymour Bernstein
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Abstract
Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.
Claims18
A compound of the formula:
- ##STR4## wherein R, R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen and methyl;
- and A is a pharmaceutically acceptable salt cation.
The compound according to claim 1, 8-[3-(3-Amino-p-toluamido)-p-toluenesulfonamido]-1,3,5-naphthalene-trisulf onic acid, trisodium salt.
The compound according to claim 1, 8-[3-(3-Amino-p-toluamido)-p-toluenesulfonamido]-1,3,6-naphthalenetrisulfo nic acid, trisodium salt.
The compound according to claim 1, 8-[3-(3-Aminobenzamido)-p-toluenesulfonamido[-1,3,6-naphthalenetrisulfonic acid, trisodium salt.
The compound according to claim 1, 8-[3-(3-Aminobenzamido)-p-toluenesulfonamido]-1,3,5-naphthalenetrisulfonic acid, trisodium salt.
The compound according to claim 1, 8-[5-(5-Amino-o-toluamido)-o-toluenesulfonamido]-1,3,5-naphthalenetrisulfo nic acid, trisodium salt.
The compound according to claim 1, 8-[5-(5-Amino-o-toluamido)-o-toluenesulfonamido]-1,3,6-naphthalenetrisulfo nic acid, trisodium salt.
The compound according to claim 1, 8-[N-(m-Aminobenzoyl)metanilamido]-1,3,5-naphthalenetrisulfonic acid, trisodium salt.
A compound of the formula:
- ##STR5## wherein R, R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen and methyl;
- and A is a pharmaceutically acceptable salt cation.
Dependencies are inferred from the claim text.