S-5-(Azidomethyl or aminomethyl)-2-lower-alkoxytetrahydrofurans
AssigneeSchering Corporation
InventorStuart McCombie
Life of this patent
Estimating the term…
Abstract
4-O-(2,3,5-Trideoxy-5-amino-.alpha.-D-pentofuranosyl)-6-O-aminoglycosyl-1,3 -diaminocyclitols and 1-N-substituted derivatives thereof are described together with methods for their preparation and their use as antibacterial agents. Preferred are 1-N-(.omega.-amino-.alpha.-hydroxyalkanoyl)-[4-O-(2,3,5-trideoxy-5-amino-. alpha.-D-pentofuranosyl)-6-O-garosaminyl-2-deoxystreptamines], particularly the 1-N-(S-.beta.-amino-.alpha.-hydroxypropionyl) derivatives, which are broad spectrum antibacterial agents.
Claims2
A lactol derivative selected from the group consisting of S-5-(azidomethyl)-2-lower alkoxytetrahydrofuran, S-5-(aminomethyl)-2-lower alkoxytetrahydrofurane, and an S-5-(N-protected aminomethyl)-2-lower alkoxytetrahydrofuran wherein said lower alkoxy has up to four carbon atoms and said N-protecting group is stable to acid and is removable with base.
Dependencies are inferred from the claim text.