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US 4,231,944 AGranted
Fluorinated polyenes
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, Beverly A. Pawson
Life of this patent
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Abstract
9-substituted, 4- or 6-fluorine substituted retinoic acid derivatives useful as antitumor agents and in the treatment of acne as well as a method for their manufacture are disclosed. Substituents at the 9-position include substituted phenyl, thienyl and furyl groups.
Claims5
A compound having the formula:
- ##STR48## wherein one of R.sub.1 and R.sub.2 is fluorine and the other is hydrogen;
- R.sub.3 is formyl, hydroxymethyl, alkoxymethyl, carboxyl, alkoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl or di(lower alkyl)-carbamoyl;
- R.sub.8 and R.sub.11 each are lower alkyl;
- R.sub.9 is hydrogen or lower alkyl;
- and R.sub.10 is oxygen;
- or pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.