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US 4,231,936 AGranted
Mitomycin C derivatives
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsKinichi Nakano, Chikahiro Urakawa, Ryoji Imai
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Abstract
The present invention provides new derivatives of mitomycin C, represented by the formula: ##STR1## wherein R represents a hydroxy group in which case the composition is designated as 7-N-(p-hydroxyphenyl)-mitomycin C or an amino group in which case it is designated as 7-N-(p-aminophenyl)-mitomycin C. The new compounds are produced by reacting mitomycin A with p-aminophenyl or p-phenylenediamine and exhibit good antitumor and antibacterial activities.
Claims3
A compound of the formula:
- ##STR6## wherein R is selected from the class consisting of a hydroxy group and an amino group.
7-N-(p-hydroxyphenyl)-mitomycin C.
7-N-(p-aminophenyl)-mitomycin C.
Dependencies are inferred from the claim text.