Hydrazono penicillin derivatives
AssigneeCRAF Sud
InventorsRiccardo Monguzzi, Giorgio Pifferi, Mario Pinza, Giampietro Broccali
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Abstract
Hydrazono penicillin derivatives of the formula ##STR1## wherein R represents phenyl optionally substituted, 2- or 3- thienyl optionally substituted, or 2- or 3-furyl optionally substituted, R.sub.1 represents hydrogen, alkyl containing from 1 to 4 carbon atoms, or phenyl, and R.sub.2 represents hydrogen, pivaloyloxymethyl, or 1-(ethoxycarbonyloxy)ethyl radical. The compounds have antibacterial activity against gram-negative and gram-positive microorganisms. Methods of preparation are also disclosed.
Claims7
Hydrazono penicillin of the formula ##STR5## wherein R represents phenyl, 2- or 3- thienyl or 2- or 3- furyl, R.sub.1 represents hydrogen or alkyl containing from 1 to 4 carbon atoms, R.sub.2 represents hydrogen, sodium, potassium, pivaloyloxymethyl or 1-(ethoxycarbonyloxy)-ethyl, in separated form E or Z or mixture of the same.
6-(.alpha.-Methylhydrazonophenylacetamido)penicillanic acid sodium salt.
Pivaloyloxymethyl ester of 6-(.alpha.-methylhydrazonophenylacetamido)penicillanic acid.
Pivaloyloxymethyl ester of 6-(.alpha.-methylhydrazonofurylacetamido)penicillanic acid.
Ethoxycarbonyloxy-1-ethyl ester of 6-(.alpha.-methylhydrazonophenylacetamido)penicillanic acid.
Pivaloyloxymethyl ester of 6-(.alpha.-hydrazonophenylacetamido)penicillanic acid (Z).
Pivaloyloxymethyl ester of 6-(.alpha.-hydrazonophenylacetamido)penicillanic acid (E).
Dependencies are inferred from the claim text.