Process for preparing 2-(3-benzoylphenyl)-propionic acid
AssigneeLEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o.
InventorsBoris Zupancic, Mirko Sopoic
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Abstract
Process for preparing 2-(3-benzoylphenyl)-propionic acid or salt thereof which includes methylating 3-benzoyl-phenyl acetonitrile or an alkoxide thereof in the presence of neutral non-cyclic ligands with an open polyether chain.
Claims5
Process for preparing 2-(3-benzoylphenyl)-propionic acid or salt thereof wherein 3-benzoylphenyl acetonitrile or an alkoxide thereof comprising 1 to 4 carbon atoms in the alkoxy moiety are reacted with a methylating agent in a two-phase system under conditions of phase transfer catalysis, whereupon the mixture is hydrolysed and optionally the obtained acid is converted into a metal salt or an addition salt of a nitrogen-containing base, characterized in that the methylation is performed in the presence of neutral non-cyclic ligands with an open polyether chain as a catalyst at a temperature within the range of -10.degree. to +50.degree. C.
Dependencies are inferred from the claim text.