Polyene compounds
AssigneeHoffmann-La Roche Inc.
InventorsMichael J. Klaus, Beverly A. Pawson
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Abstract
Novel 9-substituted or unsubstituted thienyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives, useful as antitumor agents as well as processes for their preparation and novel intermediates are disclosed.
Claims19
A compound represented by the formula ##STR23## wherein one of R.sub.1 or R.sub.2 is ##STR24## and the other of R.sub.1 or R.sub.2 and R.sub.3 and R.sub.4 are hydrogen, lower alkoxy-lower alkyl, hydroxy methyl, halogen, lower alkyl, lower alkoxy, amino, carboxyl, mono(lower alkyl)amino, lower alkyl thio, di(lower alkyl)amino, mono(lower alkyl)amino lower alkyl, di(lower alkyl)amino lower alkyl, hydroxy, lower alkenyl, lower alkenoxy, lower alkanoyl, lower alkanoyloxy, nitro, lower alkoxycarbonyl, lower alkanoylamido or a nitrogen containing heterocycle, selected from the group consisting of piperidino, morpholino, thiomorpholino and pyrrolidino and R.sub.5 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, alkoxycarbonyl, aroyloxymethyl or an N-heterocyclylcarbonyl selected from the group consisting of piperidino, morpholino, thiomorpholino and pyrrolidino;
- with the proviso that when R.sub.5 is alkoxycarbonyl, at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is lower alkoxy-lower alkyl, hydroxy methyl, halogen, lower alkoxy, amino, carboxyl, mono(lower alkyl)amino, lower alkyl thio, di(lower alkyl)amino, mono(lower alkyl)amino lower alkyl, di(lower alkyl)amino lower alkyl, hydroxy, lower alkenyl, lower alkenoxy, lower alkanoyl, lower alkanoyloxy, lower alkoxycarbonyl, lower alkanoylamido or a nitrogen containing heterocycle, selected from the group consisting of piperidino, morpholino, thiomorpholino and pyrrolidino.
The compound according to claim 1, 3,7-dimethyl-9-(2,4-dimethyl5-methoxymethyl-3-thienyl)-2,4,6,8-nonatetraen oic acid ethyl ester.
Dependencies are inferred from the claim text.