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US 4,230,860 AGranted
Processes for the separation of enantiomers by selective crystallization
AssigneeAmerican Cyanamid Company
InventorSivaraman Raghu
Life of this patent
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Abstract
Processes for separating racemic trans-1,2-cyclic dicarboxylic acids by dissolving the racemic acid and a resolving agent such as cinchonidine in a solvent and cooling the solvent to form crystals rich in d-trans-1,2-cyclobutane dicarboxylic acid, the d-trans acid being recovered for use in preparing optically active materials.
Claims8
A process for preparing the d-enantiomer of trans-1,2-cyclobutane dicarboxylic acid which consists essentially in the steps of:
- dissolving racemic trans-1,2-cyclobutane dicarboxylic acid and cinchonidine in an aqueous solvent to form a solution thereof, cooling the latter solution, and recovering thus-formed crystals enriched in d-trans-1,2-cyclobutane dicarboxylic acid.
Dependencies are inferred from the claim text.