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US 4,230,854 AGranted
Analogues of ergot alkaloids
AssigneeSocieta' Farmaceutici Italia S.p.A.
InventorsEnzo Beacco, Maria L. Bianchi, Annacleto Minghetti, Celestino Spalla
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Abstract
Ergot alkaloids having interesting pharmacological activities, for instance in the therapy of migraine or hypertension. Such compounds are obtained in a fermentative process using mutant strains of Claviceps purpurea eventually hydrogenating the products thus obtained.
Claims1
Ergot alkaloids of formula ##STR3## and their 9,10 dihydroderivatives, wherein R.sub.1 is selected from the group consisting of methyl, ethyl and isopropyl;
- R.sub.2 is selected from the group consisting of ##STR4## halogen-substituted linear C.sub.3 -C.sub.5 alkyl-group and halogen-substituted isobutyl-group;
- R.sub.3 being selected from the group consisting of C.sub.1 -C.sub.4 alkyl and halogen.
Dependencies are inferred from the claim text.