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US 4,230,848 AGranted
Process for producing 3-O-demethylfortimicins
AssigneeAbbott Laboratories
InventorWilliam Rosenbrook, Jr.
Life of this patent
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Abstract
An improved process for producing 3-O-demethylfortimicins comprising the steps of reacting the fortimicin to be 3-O-demethylated with a borontrihalide and recovering the 3-O-demethylfortimicin from the reaction mixture.
Claims12
A method of O-demethylating a fortimicin antibiotic comprising the steps of dissolving a fortimicin to be O-demethylated in an inert solvent, cooling the resulting solution to a temperature of from -72.degree. to 4.degree. C., treating said cooled solution with a boron trihalide and thereafter recovering the O-demethylated antibiotic from the reaction mixture.
Dependencies are inferred from the claim text.