Back to results
US 4,230,845 AGranted
Polyhydroxy-alkyl-3,5-disubstituted-2,4,6-triiodocarbanilates
AssigneeMallinckrodt Inc.
InventorKenneth R. Smith
Life of this patent
Estimating the term…
Abstract
Certain polyhydroxy-alkyl-3,5-disubstituted-2,4,6-triiodocarbanilates are useful as x-ray contrast agents. Representative of this class of compounds is the compound 1-[N-(2,4,6-triiodo-3-N,N-dimethylcarbamyl-5-N-methylcarbamyl)carbanilyl]- L-sorbose.
Claims7
A compound of the formula:
- ##STR26## wherein X and Y are each selected from the group consisting of lower alkoxy, hydroxy-(lower alkoxy), lower alkoxy-(lower alkoxy), lower acylalkyl), lower acylamino-(lower acylamino), hydroxy-lower acylamino, N-(lower alkyl)-lower acylamino, lower alkylsulfonamido, N-(lower alkyl)-lower alkylsulfonamido, 3,3-bis-(lower alkyl)-ureido, lower perfluoroacylamino, carbamyl, N-(lower alkyl) carbamyl, N,N-di-(lower alkyl) carbamyl, lower alkoxy-(lower acylamino), lower alkoxy-alkoxy(lower acylamino), hydroxy and hydroxy-lower alkyl functions and Z is the monovalent residue of a polyol selected from the group consisting of cyclic polyols, acylamino polyols and alkyl glycosides, said monovalent residue containing not more than 7 carbon atoms in its chain or ring.
A compound of the formula:
- ##STR28## wherein X and Y are each selected from the group consisting of lower alkoxy, lower alkoxy-(lower alkoxy), lower acylamino, lower acylamino-(lower alkyl), lower acylamino-(lower acylamino), N-(lower alkyl)-lower acylamino, lower alkylsulfonamido, N-(lower alkyl)-lower alkylsulfonamido, 3,3-bis-(lower alkyl)-ureido, lower perfluoroacylamino, carbamyl, N-(lower alkyl) carbamyl, N,N-di-(lower alkyl) carbamyl, lower alkoxy-(lower acylamino), lower alkoxyalkoxy-(lower acylamino) functions and ester, acetal or ketal derivatives of hydroxy, hydroxy-lower alkyl, hydroxy-(lower alkoxy) and hydroxy-lower acylamino functions and Z.sub.p is selected from the group consisting of ester, acetal and ketal derivatives of a monovalent residue of a polyol selected from the group consisting of cyclic polyols, acylamino polyols and alkyl glycosides, said derivatives containing at least one hydroxyl group in an unprotected form and said monovalent residue containing not more than 7 carbon atoms in its chain or ring.
Dependencies are inferred from the claim text.