Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom
AssigneeSchering Corporation
InventorsDavid Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
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Abstract
A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotoc W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
Claims4
A process for preparing Antibiotic W-10 Complex which comprises cultivating under controlled aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen an Antibiotic W-10 Complex producing member of Aeromonas sp. W-10 until a composition of matter having substantial antifungal activity is produced and recovering the Antibiotic W-10 Complex from said medium.
Dependencies are inferred from the claim text.