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US 4,230,727 AGranted
Compositions and method of treatment
AssigneeWilliam H. Rorer, Inc.
InventorsGeorge W. Nuss, Jr., Norman J. Santora, George H. Douglas
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Abstract
Compositions for inhibiting cellular proliferation in mammals containing as the active ingredient N-benzylideneaniline and its derivatives, and the method therefor.
Claims27
A method of inhibiting or preventing cellular proliferation in mammals which comprises administering to a mammal in need of treatment an effective amount of a compound of the formula:
- ##STR5## where:
- R is hydrogen or alkyl;
- R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 may be the same or different and are
- hydrogen,
- alkyl,
- nitro,
- amino,
- haloloweralkoxy,
- haloloweralkyl,
- halo,
- loweralkoxy,
- hydroxy,
- carboxy and
- carbalkoxy;
- and
- R.sub.3 and R.sub.8 may also be cycloalkyl, cycloalkenyl or aryl in a suitable pharmaceutically acceptable carrier.
13 more elements
Dependencies are inferred from the claim text.