Amide derivatives of 2-substituted anilino-hexahydrobenzo[a]quinolizines, and methods of treating hypertension employing them
AssigneeMiles Laboratories, Inc.
InventorsHerbert J. Havera, Wallace G. Strycker
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Abstract
Disclosed are novel 2-substituted anilino-hexahydrobenzo[a]quinolizines of the formula: ##STR1## wherein R and R' are independently H or --OCH.sub.3 and R" is ##STR2## These compounds, and their pharmacologically acceptable, non-toxic acid addition salts are useful as anti-hypertensive agents. Certain of the compounds disclosed herein elicit this effect without producing concomitant cardiac stimulation.
Claims20
2-substituted anilino-hexahydrobenzo[a]quinolizines of the formula:
- ##STR19## wherein R and R' are independently H or OCH.sub.3 and R" is ##STR20## and pharmacologically acceptable, non-toxic acid addition salts thereof.
A method of treating hypertension in an individual requiring such treatment which method comprises administering to said individual an effective amount of a compound of the formula:
- ##STR30## wherein R and R' are independently H or OCH.sub.3 and R" is ##STR31##
Dependencies are inferred from the claim text.