Antihypertensive quinazoline compounds
AssigneeSumitomo Chemical Company, Limited
InventorsIsamu Maruyama, Shunji Aono, Junki Katsube
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Abstract
Quinazoline compounds of the formula: ##STR1## wherein A is ##STR2## wherein n is an integer of 1 or 2, or ##STR3## wherein X is O or CH.sub.2, and n and m are independently an integer of 1 or 2, and its non-toxic pharmaceutically acceptable salts, having an excellent antihypertensive activity without causing adverse effects such as orthostatic hypotension.
Claims9
A compound of the formula:
- ##STR10## wherein A is ##STR11## wherein n is an integer of 1 or 2, or ##STR12## wherein X is O or CH.sub.2, and n and m are independently an integer of 1 or 2, and its non-toxic pharmaceutically acceptable salts.
2-{4-(1-Adamantanecarbonyl)-1-piperazinyl}-4-amino-6,7-dimeth oxyquinazoline, and its pharmaceutically acceptable salts.
4-Amino-6,7-dimethoxy-2-[4-{3-oxatricyclo[4,2,1,0.sup.4,8 ]nonane-1-carbonyl}-1-piperazinyl]quinazoline, and its pharmaceutically acceptable salts.
4-Amino-6,7-dimethoxy-2-[4-{3-oxatricyclo[4,3,1,0.sup.4,9 ]decane-1-carbonyl}-1-piperazinyl]quinazoline, and its pharmaceutically acceptable salts.
4-Amino-6,7-dimethoxy-2-[4-{3-oxatricyclo[4,2,1,0.sup.4,8 ]nonane-9-carbonyl}-1-piperazinyl]quinazoline, and its pharmaceutically acceptable salts.
4-Amino-2-[4-{b icyclo[2,2,1[hept-2-ene-5-carbonyl}-1-piperazinyl]-6,7-dimethoxyquinazoline , and its pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.