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US 4,230,701 AGranted
Administration of biologically active vitamin D.sub.3 and vitamin D.sub.2 materials
AssigneeHoffmann-La Roche Inc.
InventorsMichael F. Holick, Milan R. Uskokovic
Life of this patent
Estimating the term…
Abstract
A process for administering biologically active vitamin D.sub.3 and vitamin D.sub.2 materials into the blood system of a subject by providing the biologically active vitamin D.sub.3 or D.sub.2 material to the skin whereby the skin releases the biologically active vitamin D.sub.3 or D.sub.2 material into the blood system in a controlled and prolonged manner.
Claims6
A composition useful for treating disorders due to decreased calcium transport in the form of a topical preparation suitable for application to the skin comprising a therapeutic amount of a material selected from the group consisting of:
- ##STR4## wherein R is methylidene or methyl;
- R.sub.2 is hydrogen, hydroxy or methyl;
- R.sub.1, R.sub.3 and R.sub.4 are hydrogen, hydroxy or halogen;
- A and B are individually hydrogen or taken together form a carbon to carbon bond;
- with the proviso that at least one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is hydroxy and with the further proviso that when A and B form a carbon to carbon bond, R.sub.2 is methyl, and a suitable inert carrier for topical preparation.
2 more elements
Dependencies are inferred from the claim text.