Methods for inhibiting mobilization of calcium phosphate in animal tissue
AssigneeThe Procter & Gamble Company
InventorMarion D. Francis
Life of this patent
Estimating the term…
Abstract
Compositions for inhibiting the anomalous mobilization of calcium phosphates in animal tissue comprising an effective amount of certain phosphonate compounds as herein defined in combination with Vitamin D-like antirachitic compounds, and a method for treating or preventing conditions involving hard tissue demineralization in an animal comprising concurrently administering said phosphonates and Vitamine D-like antirachitic compounds to animals.
Claims21
A method of treating Paget's disease comprising conjointly administering to an animal afflicted therewith therapeutic dosages of a phosphonate selected from the group consisting of:
- ##STR9## wherein each p is hydrogen or CH.sub.2 OH and n is an integer of from 3 to 10:
- ##STR10## wherein R.sub.1 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenylethenyl, benzyl, halogen, hydroxyl, amino, dimethylamino, diethylamino, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, CH(PO.sub.3 H.sub.2)(OH), or --[CH.sub.2 C(PO.sub.3 H.sub.2).sub.2 ].sub.n H wherein n is 1 to 15, R.sub.2 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, or --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2;
- ##STR11## wherein n is an integer of from 3 to 9;
- ##STR12## wherein each R.sub.3 is hydrogen or lower alkyl;
- ##STR13## wherein n is an integer of from 2 to 4;
- ##STR14## wherein X and Y are each hydrogen or hydroxy;
- ##STR15## and the pharmaceutically acceptable salts thereof;
- and (2) from about 100 I.U. to about 50,000 I.U. of a Vitamin-D active antirachitic compound.
A method of treating osteoporosis comprising conjointly administering to an aminal afflicted therewith therapeutic dosages of a phosphonate selected from the group consisting of:
- ##STR16## wherein each P is hydrogen or CH.sub.2 CH and n is an integer of from 3 to 10:
- ##STR17## wherein R.sub.1 is hydrogen, alkyl containing from 1 to about 20 carbon atoms, alkenyl containing from 2 to about 20 carbon atoms, phenylethenyl, benzyl, halogen, hydroxyl, amino, dimethylamino, diethylamino, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, CH(PO.sub.3 H.sub.2)(OH), or --[CH.sub.2 C(PO.sub.3 H.sub.2).sub.2 ].sub.n H wherein n is 1 to 15, R.sub.2 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, --CH.sub.2 COOH, --CH.sub.2 PO.sub.3 H.sub.2, or --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2 ;
- ##STR18## wherein n is an integer of from 3 to 9:
- ##STR19## wherein each P.sub.3 is hydrogen or lower alkyl;
- ##STR20## wherein n is an integer of from 2 to 4;
- ##STR21## wherein X and Y are each hydrogen or hydroxy;
- ##STR22## and the pharmaceutically acceptable salts thereof, and (2) from about 100 I.U. to about 50,000 I.U. of a Vitamin-D active antirachitic compound.
Dependencies are inferred from the claim text.