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AssigneesDirector-General of Agency of Industrial Science and Technology, Nihon Tenganyaku Kenkyusho Co., LTD.
InventorsAizo Yamauchi, Yasuo Matsuzawa, Sadayoshi Kamiya, Keisuke Nishioka, Yoshiaki Hara, Shogo Matsushima
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The invention presents a high-viscosity eye lotion with which lasting curve effects can be obtained with no feeling of foreign bodies to the eye as in the conventional eye salves used in treating eyes. The high-viscosity eye lotion of the invention comprises a swollen hydrated gel of a crosslinked polyvinyl alcohol and an eye-disease curative active ingredient contained therein. It is prepared by irradiating an aqueous solution of a polyvinyl alcohol with an ionizing radiation to such an extent that the polyvinyl alcohol is crosslinked to give a hydrated gel with an equilibrium swelling ratio in the range from 70 to 100 by weight and then dipping the hydrated gel in an aqueous solution of the eye-disease curative active agent.
high-viscosity eye lotion comprising a flowable swollen hydrated gel of a cross-linked polyvinyl alcohol having an equilibrium swelling ratio in the range from 70 to 100 by weight at room temperature as a carrier medium and an ophthalmically active ingredient in a therapeutically effective concentration in said carrier medium.
A method for preparing a high-viscosity eye lotion which comprises subjecting an aqueous solution of a polyvinyl alcohol to irradiation with an ionizing radiation to such an extent that the polyvinyl alcohol is crosslinked to give a hydrated gel with an equlibrium swelling ratio in the range from 70 to 100 by weight at room temperature and impregnating the thus obtained hydrated gel of the crosslinked polyvinyl alcohol with an eye-disease curative active ingredient in a therapeutically effective concentration.
Dependencies are inferred from the claim text.