Acyclic carboxamides having a physiological cooling effect
AssigneeWilkinson Sword Limited
InventorsDavid G. Rowsell, David J. Spring, Roger Hems
Life of this patent
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Abstract
Compositions are disclosed having a physiological cooling action on the skin. The compositions contain, as the active ingredient, certain acyclic tertiary and secondary carboxamides.
Claims15
In a manufactured consumer product for application to or consumption by the human body, said product comprising a vehicle topically administrable to or consumable by the human body and containing as an adjuvant in said vehicle, a compound capable of stimulating the cold receptors of the nervous system in the surface tissues of the body when brought into contact therewith by topical application or consumption of the said vehicle, said product being:
- (i) A toiletry comprising a topically administrable vehicle containing as adjuvants therein (a) said cold receptor stimulating compound and (b) at least one of the following:
- an odourant, antiseptic, colourant or surfactant;
- (ii) a foodstuff or beverage comprising an orally ingestible vehicle containing as adjuvants therein (a) said cold receptor stimulating compound and (b) a flavourant;
- or
- (iii) a tobacco or tobacco-containing manufacture containing said cold receptor stimulating compound;
- the improvement which comprises using as said cold receptor stimulating compound an effective amount of a cold receptor stimulating acyclic carboxamide of the formula:
- ##STR5## wherein R" is C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl or alkylcarboxyalkyl of up to 6 carbon atoms;
- R.sub.1 is H or C.sub.1 -C.sub.5 alkyl;
- and
- R.sub.2 and R.sub.3 are each C.sub.1 -C.sub.5 alkyl;
- with the provisos that
- (i) R.sub.1, R.sub.2 and R.sub.3 together provide a total of at least 5 carbon atoms;
- and
- (ii) when R.sub.1 is hydrogen then R.sub.2 is C.sub.2 -C.sub.5 alkyl and R.sub.3 is C.sub.3 -C.sub.5 alkyl branched at the carbon atom in the alpha or beta position.
A method of stimulating the cold receptors of the nervous system in the surface tissues of the human body which comprises contacting said receptors with an effective amount of a cold receptor stimulating acyclic carboxamide of the formula:
- ##STR6## wherein R" is C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl or alkylcarboxyalkyl of up to 6 carbon atoms;
- R.sub.1 is H or C.sub.1 -C.sub.5 alkyl;
- and
- R.sub.2 and R.sub.3 are each C.sub.1 -C.sub.5 alkyl;
- with the provisos that
- (i) R.sub.1, R.sub.2 and R.sub.3 together provide a total of at least 5 carbon atoms;
- and
- (ii) when R.sub.1 is hydrogen then R.sub.2 is C.sub.2 -C.sub.5 alkyl and R.sub.3 is C.sub.3 -C.sub.5 alkyl branched at the carbon atom in the alpha or beta position.
Dependencies are inferred from the claim text.