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US 4,230,635 AGranted
Substituted 4'-polyhaloisopropylsulfonanilides
AssigneeSchering Corporation
InventorBernard R. Neustadt
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Abstract
Disclosed are novel substituted 4'-polyhaloisopropylsulfonanilides which are anti-hypertensive agents useful in the treatment of mammalian hypertension. Additionally, the compounds exhibit herbicidal and fungicidal activity. The compounds are prepared by contacting a 4-polyhaloisopropylaniline with the appropriate substituted-sulfonyl chloride.
Claims18
A compound of the formula:
- ##STR5## wherein R is hydrogen, lower alkyl, or a lower alkylsulfonyl group;
- R.sub.1 is hydrogen, lower alkyl, lower alkoxy, or halogen;
- R.sub.2 is hydrogen, lower alkyl, lower alkoxy, or halogen;
- R.sub.3 is hydrogen or lower alkyl, or R.sub.1 and R.sub.3 together complete an aromatic fused hydrocarbon ring;
- R.sub.4 is lower alkyl;
- Y, Y.sub.1, Y.sub.2, and Y.sub.3 are independently hydrogen, chlorine or fluorine;
- and
- Z is hydrogen, chlorine, fluorine, or hydroxy.
5 more elements
Dependencies are inferred from the claim text.