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US 4,230,628 AGranted
4-[(Carboxyl- and sulfamyl-substituted alkyl)-amino] benzoic acids and analogs
AssigneeAmerican Cyanamid Company
InventorRobert G. Shepherd
Life of this patent
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Abstract
This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.
Claims5
A compound of the formula:
- ##STR2## wherein X is selected from the group consisting of carboxy, lower alkoxycarbonyl and aryloxycarbonyl;
- A is an unbranched or branched alkylene group optionally saturated or mono- or poly-unsaturated, and containing or not containing a cycloalkyl group, represented by the formula C.sub.n H.sub.2(n-p) with n being an integer from 8 to 18, inclusive, and p being an integer from 0 to 5, inclusive;
- and Z is selected from the group consisting of hydroxy, lower alkoxy, lower alkoxyalkoxy, di(lower alkyl)aminoalkoxy, (mono- or poly-hydroxy)lower alkoxy, allyloxy and substituted or unsubstituted benzyloxy;
- and the pharmaceutically acceptable non-toxic acid-addition and cationic salts thereof.
1 more element
The compound 4-(15-carbomethoxypentadecylamino)benzoic acid.
The compound ethyl 4-(15-carbomethoxypentadecylamino)benzoate.
The compound 4-(10-carboxydecylamino)benzoic acid.
The compound 4-(15-carboxypentadecylamino)benzoic acid.
Dependencies are inferred from the claim text.