Process for chenodeoxycholic acid and intermediates therefore
AssigneeHoffmann-La Roche Inc.
InventorsCarl Despreaux, Thomas A. Narwid, Norberto J. Palleroni, Milan R. Uskokovic
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Abstract
A multi-step synthesis of chenodeoxycholic acid from 3-keto-bisnorcholenol, a compound readily obtained from the abundant plant sterol .beta.-sitosterol, is described. A key step in the synthesis is the stereoselective microbial introduction of the 7-alpha hydroxy group into 3-keto-bisnorcholenol.
Claims15
(5.beta.)-24-Norcholane-3.alpha.,7.alpha.-diol-23,23-dicarboxylic acid.
A compound of the formula ##STR12## where Y is C.sub.1-3 -alkyl.
A compound of the formula ##STR13## where Y is C.sub.1-3 -alkyl.
A compound of the formula ##STR14## where X is methyl or p-tolyl.
(5.beta.)-7.alpha.,22-Dihydroxy-23,24-bisnorcholan-3-one.
7.alpha.,22-Dihydroxy-23,24-bisnorchol-4-en-3-one.
A compound of the formula ##STR15## where X is methyl or p-tolyl.
A compound of the formula ##STR16## where X is methyl or p-tolyl and R is acyl.
A compound of the formula ##STR17## where R is acyl and Y is C.sub.1-3 -alkyl.
Dependencies are inferred from the claim text.